Yeast is a type of fungus that may be present normally over the skin. The specific type of yeast that causes many a diseases in human is Candida albicans. This is a normal flora, mainly showing their presence in the moist areas of human skin like armpits, mouth, groin, sexual organs (both in male and female) and fold of the buttocks. It is seen that 20-50% of any normal healthy female carry yeast in their vaginal area.
Candidiasis, or yeast infection can be localized to the skin or there may be severe systemic infection in patients having reduced immunity. These patients usually suffer from AIDS, cancer or cancer patients receiving chemotherapy drugs.
It is estimated that almost 75% of the female population will suffer from vaginal yeast infection at any point of their lifetime. This is again aggravated by previous or secondary bacterial infection like Gonorrhea and protozoal infection like Trichomonas. Some external irritants like vaginal douches or the internal hormonal disturbances derange the normal vaginal flora and there is excess production of the acid producing bacteria like lactobacilli. Regular intake of oral pills, pregnancy, stress, vaginal sex immediately after anal sex and private part lubricants containing glycerin are some predisposing factors of vaginal yeast infection.
Men can also suffer from genital yeast infection. The causes are unclean prepuce, engaging in excessive anal sex and not cleaning after that.
Oral candidiasis can occur in immunocompromized patients. This may also transmit to any person if engaged in oral sex with the infected partner. Long standing diabetes is one of the most contributory factors of oral yeast infection.
Use of antibiotics and steroids (which lowers the immunity) is the two most common causes of yeast infection of mouth cavity and private parts due to indiscriminate use by the doctors and also by the quacks. To kill this offending fungus we need some medicine called antifungal agents. Diflucan is one of them.
Diflucan, or scientifically known as Fluconazole, is an imidazole related antifungal agent which shows primary a fungistatic (inhibiting the growth of fungus) action. But in higher concentrations, Diflucan can also acts as a fungicidal agent (killing fungus). It helps to destroy the cytoplasmic membrane of the fungus and the fungal growth is retarded.
Bioavailability of Diflucan is not affected by presence of food in stomach. After absorption, it promptly shows its presence in skin, tears and urine. The concentration here are at least 10 times more that in sputum, saliva and vaginal fluid. This delineates the excretory process of Diflucan through urine and sweat. This is the reason Diflucan is preferred by doctors treating the cases of skin and vaginal yeast infection.
Patients having irregular heart rate and liver diseases must not take Diflucan as there may be aggravation of the problem. Although Diflucan is well tolerated generally, people can suffer from nausea, vomiting, abdominal cramps and diarrhea infrequently.
The major complications of Diflucan are reduced urine output, ulcerative condition of the lips and gums (Steven-Johnson’s Syndrome). Presence of Diflucan is noted in the breast milk, so nursing mothers should not take this medicine. Diflucan can lead to fetal malformations, therefore the pregnant mothers and those who are planning to have a baby in near future should avoid using Diflucan.
Diflucan is a good medicine in Yeast infection but the side effects are the restrictive factors for the wide use of this drug.